Triplexator A computational toolkit for the prediction of nucleic acid triple helices
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find dna acid

Triplexator Description

Double-stranded DNA is able to form triple-helical structures by accommodating a third nucleotide strand in its major groove. This sequence-specific process offers a potent mechanism for targeting genomic loci of interest, that is of great interest for bio-technological and gene-therapeutic applications.Triplex-formation requires a duplex, presumably DNA, and a single-stranded nucleotide sequence acting as the third strand, presumably RNA.The process of predicting putative triplexes in sequence data can be divided into three steps:· identifying the triplex-forming oligonucleotides (TFO) in single-stranded sequences· identifying the triplex target sites in double-stranded sequences able to accomondate a third strand· assessing the compatibility of potential TFO/TTS pairs according to the canonical triplex formation rules Triplexator is an application that uses approximate pattern matching based on the triplex formation rules in order to find putative TFO-TTS pairs (triplexes) in two sets of nucleotide sequences, where one set contains the duplex sequences and the other thDetailed instructions on how to install and use the Triplexator utility on your Mac are available HERE.

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